The abandoned Sir John Carling Building on the Central Experimental Farm will be torn down Sunday.
The structure, which served as the headquarters for Agriculture and Agri-Food Canada from 1967 to 2009, will be demolished early that morning with explosives and there will be several road closures in the area as a precaution.
The 11-storey building has two basement levels and a floor area of more than 40,000 square metres.
It was recognized as a federal heritage building in 2004, but it was decided in June 2012 that the structure would be demolished.
AIM Waste Management Inc. was awarded a $4.8-million contract in January 2013 to deconstruct the building.